Incidence of retropharyngeal lymph node involvement in oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis.
Oral OncolJul 31, 2026 (epub)
Suliman Ali, Muhammad Elkarim S Mohammed, Mohammed Yousif et al.
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In 30 seconds
This systematic review and meta-analysis examined the incidence of retropharyngeal lymph node (RPN) involvement in oropharyngeal squamous cell carcinoma (OPSCC) across 14 studies involving 8,887 patients. The pooled prevalence of RPN involvement was found to be 11-16%. Notably, HPV-negative tumors had a higher prevalence (21% vs 11%) compared to HPV-positive tumors.
Key findings
- Pooled prevalence of RPN involvement in OPSCC was 11-16%.
- HPV-negative tumors showed a higher prevalence of RPN involvement at 21% compared to 11% in HPV-positive tumors.
- Prevalence of RPN involvement increased from 2% in T1 to 18% in T4 disease.
- The distant metastasis rate among patients with RPN involvement was 16%.
Why it matters
Understanding the prevalence of RPN involvement in OPSCC is crucial for prognosis and treatment planning. This information can guide clinicians in staging and tailoring treatment strategies for patients, particularly those with higher-risk features.