Effects of Exergame Balance Training with Variable Cognitive Motor Challenges on Serum BDNF, p-tau181, and Cognitive Functions in Adults with Mild Cognitive Impairment: A Randomized Trial.
Games Health JJul 30, 2026 (epub)
Aruba Saeed, Imran Amjad, Abdullah Alzahrani et al.
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In 30 seconds
This randomized controlled trial investigated the effects of cognitive-motor exergame balance training on serum BDNF, p-tau181, and cognitive functions in 97 adults with mild cognitive impairment (MCI). Results indicated a significant increase in serum BDNF and a reduction in p-tau181, alongside improvements in attention, abstraction, and visuospatial skills, particularly in moderate and high-difficulty training groups.
Key findings
- Serum BDNF levels increased significantly with exergame training, F (3,92) = 6.413, P = 0.017.
- p-tau181 levels decreased significantly, F (3,92) = 4.640, P = 0.040.
- Cognitive improvements were noted in attention, abstraction, and visuospatial skills, with F values ranging from 4.171 to 6.931.
- Greater effects were observed in moderate and high-difficulty training groups.
Why it matters
The findings suggest that engaging in cognitive-motor exergame balance training can enhance neurobiological markers and cognitive functions in adults with MCI, potentially offering a non-pharmacological intervention to improve patient outcomes.