Low-Grade and Intermediate-Grade Apocrine Intraductal Carcinoma Arising in a Nevus Sebaceous of Jadassohn.
Diego Hernández De Jesús, María Jesús Barros Eyzaguirre, Catalina Axpe Gil et al.
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Case in brief
A 93-year-old woman had low- and intermediate-grade apocrine intraductal carcinoma arising in a nevus sebaceous of Jadassohn. Histology showed solid and cribriform growth with focal comedonecrosis; p63 and CK5/6 highlighted an intact surrounding myoepithelial layer. Tumor cells expressed CK7, EMA, and androgen receptor, but not estrogen receptor, progesterone receptor, or HER2. Basal cell carcinoma, trichoblastoma, and apocrine hidrocystoma were also present in the nevus sebaceous.
What made this case unusual
The carcinoma arose alongside three other adnexal neoplasms in the same nevus sebaceous, and its morphology and immunophenotype closely resembled mammary apocrine ductal carcinoma in situ.
Diagnostic / clinical pearl
In an apocrine intraductal lesion, an intact myoepithelial layer and the tumor’s immunophenotype can help characterize the neoplasm; here, the findings paralleled mammary apocrine ductal carcinoma in situ.
Why it matters
The case adds to the limited literature on apocrine intraductal carcinoma arising in nevus sebaceous and illustrates the range of neoplasms that may coexist within one lesion.