Specialized pro-resolving mediators in obesity and overweight conditions: A systematic review of human and animal evidence on comparative differences and associations.
Shabnam Shahabi Nejad, Ali Nikparast, Samira Rastgoo et al.
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In 30 seconds
This systematic review examined the role of specialized pro-resolving mediators (SPMs) in obesity and overweight conditions, analyzing 27 studies across human and animal populations. The review found that overweight/obesity is often linked to lower concentrations of SPMs, particularly in adipose tissue and circulation. Notably, circulating Resolvin E1 was consistently reduced and inversely associated with adiposity measures.
Key findings
- Overweight/obesity is frequently associated with lower concentrations of SPMs in adipose tissue and circulation.
- Circulating Resolvin E1 showed reproducible reductions and was inversely associated with adiposity measures.
- Selected metabolites like Lipoxin A 4 exhibited mixed directionality across studies.
Why it matters
Understanding the relationship between SPMs and obesity can inform potential therapeutic strategies aimed at resolving inflammation and improving metabolic health. This knowledge is crucial for developing interventions that target inflammatory pathways in obesity.