Brain regional volumetric alterations in adults with bipolar disorder: A meta-analysis.
Kelei Xiao, Hisham Sayed, Jason Xing et al.
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In 30 seconds
This meta-analysis examined brain volumetric alterations in adults with bipolar disorder (BD) using DSM-IV to DSM-5-TR criteria. The study found that BD is associated with significantly greater cerebrospinal fluid (CSF), intracranial, and right lateral ventricle volumes compared to controls, indicating potential brain tissue loss. The analysis included a systematic review of relevant studies.
Key findings
- Bipolar disorder was linked to greater cerebrospinal fluid volumes compared to controls.
- Increased intracranial and right lateral ventricle volumes were also observed in individuals with bipolar disorder.
- Significant variability in CSF and intracranial volumes was noted among individuals with bipolar disorder.
- Moderate between-study heterogeneity was found, with I² approximately 51%.
Why it matters
Understanding structural brain alterations in bipolar disorder can inform clinicians about the neurobiological underpinnings of the condition, potentially guiding future research and treatment approaches. Recognizing these changes may also aid in the assessment and management of patients with BD.