Cervical length surveillance for predicting spontaneous preterm birth in women with congenital uterine anomalies: A systematic review and diagnostic accuracy meta-analysis.
Eur J Obstet Gynecol Reprod BiolJul 28, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
Nikit Kadam, Sanaria Raouf, Nia Wyn Jones et al.
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In 30 seconds
This systematic review and diagnostic accuracy meta-analysis evaluated the predictive value of transvaginal cervical length surveillance for spontaneous preterm birth (sPTB) in women with congenital uterine anomalies (CUA). Analyzing data from 5 studies involving 624 women, the findings indicated that a short cervix significantly increased the risk of sPTB, with an odds ratio of 8.05 for short cervix versus normal cervical length.
Key findings
- sPTB occurred in 52% of women with a short cervix compared to 13.2% with normal length (OR 8.05).
- A short cervix raised the risk of sPTB before 37 weeks (OR 6.68) and before 35 weeks (OR 28.16).
- The strongest association was found in women with a bicornuate uterus (OR 40.98).
- At a 25 mm cervical length, sensitivity was low while specificity was high.
Why it matters
Understanding the predictive value of cervical length in women with CUA can enhance risk stratification for sPTB, potentially guiding clinical management and monitoring strategies in this high-risk population.