Validity, responsiveness, reliability and measurement error of imaging modalities for soft tissue oedema measurements: A systematic review and best-evidence synthesis.
Eur J RadiolJul 29, 2026 (epub)
Clinical ResearchRadiology (Diagnostic)
Margje B Buitenhuis, Ceren Gürşen, Janine T Hidding et al.
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In 30 seconds
This systematic review evaluated the measurement properties of imaging modalities for assessing soft tissue oedema in adults. It included 59 studies and found that MRI demonstrated high-quality evidence for both validity and reliability in quantifying soft tissue oedema, while other modalities showed inconsistent results. The review emphasizes the need for standardized methodologies.
Key findings
- High-quality evidence for sufficient validity was found exclusively for MRI in quantifying fluid and soft tissue.
- MRI showed high-quality evidence for sufficient reliability in quantifying soft tissue.
- Fluorescence lymphography demonstrated high-quality reliability when assessing lymphatic flow and anatomy.
- Other imaging modalities exhibited low- to moderate-level or inconsistent evidence.
Why it matters
Understanding the effectiveness of imaging modalities in measuring soft tissue oedema is crucial for improving lymphoedema management. Reliable and valid measurement tools can enhance early detection and treatment strategies.