Treatment of Hot Flashes in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy.
ProstateAug 2, 2026 (epub)
Ellen Lund Schaldemose, Mads Hvid Poulsen, Bettina Nørby et al.
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In 30 seconds
This systematic review evaluated pharmacological and non-pharmacological interventions for treating hot flashes in men with prostate cancer undergoing androgen deprivation therapy. Among 35 studies reviewed, hormonal agents like cyproterone acetate and estrogen showed the most effectiveness, with a relative reduction in hot flash frequency ranging from -21% to -84%.
Key findings
- Hormonal treatments like cyproterone acetate and estrogen showed a relative reduction in hot flash frequency of -21% to -84%.
- Placebo effects for hot flash treatments ranged from -19% to -30%.
- Non-pharmacological interventions such as acupuncture and cognitive behavioral therapy may provide some benefit.
Why it matters
Hot flashes can significantly impact the quality of life for men undergoing treatment for prostate cancer. Understanding effective management strategies is crucial for improving patient comfort and adherence to therapy.