Clinical Heterogeneity and Long-Term Outcomes of Pediatric Gastrointestinal Stromal Tumors: A Series of Four Patients Highlighting SDH-Deficient and SDH-Intact Subtypes.

Pediatr Blood CancerAug 3, 2026 (epub)
Case ReportOncology (Medical)PediatricsGastroenterology

Hala Elfarraj, Maha Barbar, Iyad Sultan et al.

✦ AI-curated · Sources linked

Case in brief

This report details four pediatric patients with gastrointestinal stromal tumors (GISTs) over 19 years. Two patients had SDH-deficient tumors, with one experiencing metastatic relapse. The SDH-intact female patient remains in remission 8 years post-diagnosis. The male patient showed resistance to imatinib but responded to sunitinib, allowing for successful gastrectomy and subsequent management of local recurrence, leading to ongoing remission.

Diagnostic / clinical pearl

Molecular profiling is crucial in pediatric GISTs to understand the clinical heterogeneity and guide management strategies.

Source

PubMed · PMID 42544736

Published in Pediatr Blood Cancer. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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