68 Ga-Pentixafor PET/CT as a Noninvasive Alternative in Evaluation of Suspected Aldosterone-producing Adenoma.
Haniye Elahifard, Amin Saber Tanha, Sara Shakeri et al.
✦ AI-curated · Sources linked
Case in brief
A 54-year-old woman with recurrent hypertensive crises was diagnosed with a lipid-rich right adrenal adenoma. Despite inconclusive biochemical tests for pheochromocytoma and primary aldosteronism, 68 Ga-Pentixafor PET/CT revealed focal uptake in the adenoma, indicating potential aldosterone production. Medical therapy with spironolactone was initiated, leading to a positive clinical outcome.
What made this case unusual
The use of 68 Ga-Pentixafor PET/CT provided a noninvasive diagnostic alternative in evaluating suspected aldosterone-producing adenoma, contrasting with the negative findings from 68 Ga-DOTATATE PET/CT.
Diagnostic / clinical pearl
Clinicians should consider CXCR4-targeted PET/CT imaging as a valuable tool in the noninvasive assessment of suspected aldosterone-producing adenomas.
Why it matters
This case underscores the importance of advanced imaging techniques in differentiating adrenal adenomas, potentially reducing the need for invasive procedures like adrenal vein sampling.