18F-Fluciclovine (18F-FACBC) PET/MRI Findings in Tumefactive Demyelinating Lesion: A Case Report.

Clin Nucl MedMar 2, 2026 (epub)
Case ReportNeurologyOncology (Medical)Radiology (Diagnostic)

Akihiko Sakata, Shigeki Takada, Yasuhide Takeuchi et al.

✦ AI-curated · Sources linked

Case in brief

A 28-year-old man presented with acute dysarthria and right facial droop. MRI showed a horseshoe-shaped left frontal mass, initially suspected to be a tumefactive demyelinating lesion (TDL). The lesion enlarged on follow-up despite steroid pulse therapy, prompting concern for malignancy. 18F-Fluciclovine PET/MRI demonstrated moderate tracer accumulation. Surgical resection confirmed TDL.

What made this case unusual

The lesion showed moderate 18F-Fluciclovine uptake despite rapid enlargement, a combination that raised concern for glioma but was ultimately associated with TDL in this case.

Diagnostic / clinical pearl

In this case, moderate 18F-Fluciclovine uptake alongside rapid lesion growth did not establish malignancy; imaging findings required correlation with the clinical course and, ultimately, surgical pathology.

Source

PubMed · PMID 42546266

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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