Modulatory role of Blastocystis-derived solubilized antigens in colorectal carcinogenesis: A systematic review.
Nur Amani Syakirin Noor Razali, Nur Anurah Hani Mohd Akmal, Nur Eisya Wardina Mohd Khir et al.
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In 30 seconds
This systematic review examined the immunomodulatory effects of Blastocystis-derived solubilized antigens (BSA) on colorectal cancer (CRC) using six experimental studies. The findings indicate that BSA, particularly from Subtype 3, promotes CRC cell proliferation, enhances pro-inflammatory mediator expression, and reduces p53 expression. Additionally, BSA decreased the effectiveness of 5-fluorouracil in CRC treatment.
Key findings
- BSA from Subtype 3 significantly promotes colorectal cancer cell proliferation.
- BSA increases the expression of pro-inflammatory and tumor-associated mediators.
- BSA reduces p53 gene expression and decreases the effectiveness of 5-fluorouracil.
- Chemotherapy-treated CRC patients show reduced immune responsiveness compared to healthy individuals.
Why it matters
Understanding the role of intestinal parasites like Blastocystis in colorectal cancer could provide insights into disease mechanisms and treatment challenges, particularly regarding immune modulation and chemotherapy sensitivity.