Adjunctive nutritional interventions in schizophrenia: A systematic review of randomised clinical trials.
Beatriz Braga Conceição, Thassila Rayssa Arruda de Brito, Camila Nunes de Sousa Dos Santos Reis et al.
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In 30 seconds
This systematic review evaluated the effectiveness of nutritional interventions in schizophrenia, analyzing nine randomized clinical trials. The review found that probiotic-based interventions, especially with vitamin D or selenium, improved metabolic parameters, while n-3 fatty acids affected triglyceride levels. However, the findings were heterogeneous across studies.
Key findings
- Probiotic-based interventions improved metabolic parameters and inflammatory markers when combined with vitamin D or selenium.
- n-3 fatty acid supplementation showed effects on triglyceride concentrations and neurotrophic markers.
- Plant-derived bioactive compounds were linked to improvements in negative symptoms and stress-related measures.
Why it matters
Nutritional interventions may offer additional strategies to manage schizophrenia, particularly in addressing metabolic and inflammatory issues associated with the disorder and its treatment.
What to keep in mind
Methodological heterogeneity, limited sample sizes, and short follow-up durations were noted as limitations.