Modified endoscopic mucosal resection versus endoscopic submucosal dissection for rectal neuroendocrine tumors ≤10 mm: a systematic review and meta-analysis of randomized controlled trials.
Dig Liver DisAug 4, 2026 (epub)
Ke Pang, Lujing Ying, Hemiao Xu et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy of modified endoscopic mucosal resection (m-EMR) versus endoscopic submucosal dissection (ESD) for rectal neuroendocrine tumors (r-NETs) ≤10 mm, involving 440 patients across six randomized controlled trials. The study found no significant differences in histologic complete resection rates, but m-EMR was associated with shorter procedure times and lower hospitalization costs.
Key findings
- Histologic complete resection rates were similar for m-EMR and ESD (RR = 1.00, 95% CI 0.97-1.03).
- No significant differences in en bloc resection rates were observed (P = 0.75).
- m-EMR resulted in shorter procedure times compared to ESD.
- m-EMR was associated with lower hospitalization costs.
Why it matters
Understanding the comparative effectiveness and cost implications of m-EMR versus ESD is crucial for clinicians managing rectal neuroendocrine tumors, as it may influence treatment decisions and resource allocation in clinical practice.