Male reproductive surgeries and long-term kidney outcomes: a Mendelian randomization and meta-analysis of UK Biobank and FinnGen.
Ren FailAug 4, 2026 (epub)
Dianjie Zeng, Lingfei Zhu, Li Shi et al.
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In 30 seconds
This meta-analysis and Mendelian randomization study examined the long-term kidney outcomes associated with genetic liability to male reproductive surgeries in UK Biobank and FinnGen populations. It found that genetic predisposition to testicular hydrocele surgery was linked to higher odds of chronic kidney disease and other kidney disorders, while vasectomy was associated with reduced odds of pyelonephritis.
Key findings
- Genetic liability to testicular hydrocele surgery was associated with higher odds of chronic kidney disease.
- Circumcision genetic liability linked to increased odds of malignant kidney neoplasms.
- Genetic predisposition to vasectomy was associated with reduced odds of pyelonephritis.
- Testicular or scrotal surgery genetic liability correlated with increased odds of renal colic and kidney infections.
Why it matters
Understanding the relationship between male reproductive surgeries and kidney health can help clinicians identify patients at risk for kidney diseases, allowing for proactive monitoring and management strategies.