Methodological Quality and Content Analysis of Clinical Practice Guidelines for Fever Management in Children With Sickle Cell Disease.
Pediatr Blood CancerAug 4, 2026 (epub)
Clinical ResearchPediatrics
Elspeth Bittle, Tea Reljic, Ambuj Kumar et al.
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In 30 seconds
This systematic review evaluated the methodological quality and content of clinical practice guidelines (CPGs) for managing acute fever in children with sickle cell disease (SCD). Eight CPGs were identified from a search of 839 articles, with a mean quality score of 46%. None were specifically dedicated to SCD acute fever management.
Key findings
- Eight clinical practice guidelines were identified, none specifically for SCD acute fever management.
- The mean overall quality score of the CPGs was 46%, with a range of 25%-67%.
- Geographic representation of the CPGs included France, India, Italy, Nigeria, sub-Saharan Africa, the UK, and the US.
Why it matters
The findings underscore a significant gap in high-quality, evidence-based guidelines for managing acute fever in children with SCD, a population at high risk for severe complications from infections.