FAPI-negative Papillary Renal Cell Carcinoma With Markedly FAPI-avid Sacral Insufficiency Fracture.

Clin Nucl MedAug 3, 2026 (epub)
Case ReportOncology (Medical)Radiology (Diagnostic)

Enes Yerdes, Ertan Sahin

✦ AI-curated · Sources linked

Case in brief

A 77-year-old woman with papillary renal cell carcinoma underwent [68Ga]Ga-FAPI imaging. The primary tumor showed no increased FAPI uptake, but intense uptake in the sacrum raised concern for bone metastasis. MRI findings and 2-year follow-up supported a sacral insufficiency fracture, with no metastatic disease identified.

What made this case unusual

The sacral insufficiency fracture was markedly FAPI-avid despite the primary renal tumor showing no increased uptake, creating a misleading appearance of metastatic disease.

Diagnostic / clinical pearl

Intense FAPI uptake in a bone lesion is not specific for metastasis; correlate with MRI and follow-up when fracture is a possibility.

Source

PubMed · PMID 42550168

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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