Effects of an internet-based combined exercise and cognitive-behavioral therapy intervention on endocannabinoid system biomarkers and physical fitness in adults with mild-to-moderate depression: a SONRIE randomized controlled trial.
Eur Arch Psychiatry Clin NeurosciAug 4, 2026 (epub)
Manuel Ruiz-Muñoz, David Jiménez-Pavón, Inmaculada Garrido-Palomino et al.
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In 30 seconds
This SONRIE randomized controlled trial evaluated a 12-week internet-based combined exercise and cognitive-behavioral therapy intervention in 80 adults with mild-to-moderate depression. The study found a significant improvement in cardiorespiratory fitness (CRF) with a between-group difference of +81.6 m at 12 weeks, but no significant changes in endocannabinoid system biomarkers were observed.
Key findings
- The intervention improved cardiorespiratory fitness by +81.6 m at 12 weeks (p = 0.001).
- No significant time × group interaction was found for any endocannabinoid system biomarker.
- Both groups showed comparable decreases in 2-arachidonoylglycerol and anandamide.
- Exploratory muscular fitness outcomes did not reach statistical significance.
Why it matters
The study highlights the potential of integrating internet-based exercise and cognitive-behavioral therapy in treating depression, particularly in enhancing physical fitness, which is crucial for overall health and well-being.