Liquid Biopsy in Head and Neck Squamous Cell Carcinoma: A Systematic Review of the Scientific Literature.
Tabata Briaunys Milan, Cailaine Garcia Pereira, Rafael Pereira de Souza et al.
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In 30 seconds
This systematic review evaluates the role of liquid biopsy in head and neck squamous cell carcinoma (HNSCC), focusing on circulating tumor cells, ctDNA, and RNA biomarkers. It highlights ctDNA's specificity for monitoring minimal residual disease, particularly in HPV- and EBV-driven cancers. The review underscores the potential of liquid biopsies to enhance diagnostic accuracy and personalize treatment strategies.
Key findings
- ctDNA shows specificity for monitoring minimal residual disease in HPV- and EBV-driven malignancies.
- Salivary exosomes may provide high sensitivity for early-stage oral cavity lesions.
- Novel RNA species like tumor-educated platelets and circular RNAs act as stable systemic biosensors.
Why it matters
Liquid biopsy represents a noninvasive alternative to traditional tissue biopsy, potentially improving early detection and monitoring of HNSCC. Its integration into clinical practice could enhance personalized treatment approaches and improve patient outcomes.
What to keep in mind
Significant heterogeneity in isolation protocols and detection platforms limits the clinical implementation of liquid biopsy.