Primary Pulmonary Diffuse Large B-cell Lymphoma.
Victoria Shu Lin Chua, Wei Ming Chua, Charlene Yu Lin Tang
✦ AI-curated · Sources linked
Case in brief
A 72-year-old man presented with two weeks of fever and mild upper respiratory symptoms. Initial CT and ¹⁸F-FDG PET/CT showed only nonspecific dependent ground-glass opacities (GGO). As his condition progressed without a unifying diagnosis, repeat imaging three months later demonstrated progression in the lungs. CT-guided core biopsy showed primary pulmonary diffuse large B-cell lymphoma (DLBCL).
What made this case unusual
The initial imaging was largely unremarkable apart from nonspecific dependent GGO, which later progressed and was associated with primary pulmonary DLBCL.
Diagnostic / clinical pearl
Progressive diffuse GGO without a unifying diagnosis may warrant further evaluation; in this case, lung core biopsy established primary pulmonary DLBCL.
Why it matters
The report highlights that early recognition of this cause of diffuse GGO is important to avoid delays in treatment.