Changes in hippocampal functional connectivity and volume associated with cognitive improvement and decline in amnestic mild cognitive impairment following computerized cognitive training.
Yifang Zhou, Xiaowei Jiang, Linzi Liu et al.
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In 30 seconds
This randomized controlled trial investigated hippocampal changes associated with cognitive improvement in 50 individuals with amnestic mild cognitive impairment (aMCI) following computerized cognitive training (CCT). The study found a significant interaction effect of CCT on cognitive performance, specifically measured by clock drawing test (CDT) scores (F=4.322, P=0.041), indicating that CCT can enhance visuospatial abilities in aMCI patients.
Key findings
- CCT significantly improved CDT scores in aMCI patients (F=4.322, P=0.041).
- CCT altered right-hippocampal functional connectivity in aMCI, particularly in the bilateral precuneus/cuneus (F=5.429, P=0.023).
- No significant changes in hippocampal gray matter volume were observed (P>0.05).
Why it matters
Understanding the effects of cognitive training on hippocampal function and cognitive performance in aMCI can inform therapeutic strategies aimed at slowing cognitive decline and enhancing quality of life in affected individuals.