ADJUNCTIVE MANUKA HONEY ORAL RINSE IN NONSURGICAL PERIODONTAL THERAPY FOR HEMODIALYSIS PATIENTS: A RANDOMIZED CONTROLLED CLINICAL STUDY.
Asmaa Abou-Bakr, Nermeen Nagi, Mihad Ibrahim et al.
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In 30 seconds
This randomized controlled trial evaluated the effectiveness of adjunctive Manuka honey oral rinse in 140 hemodialysis patients with Stage III periodontitis undergoing nonsurgical periodontal therapy. The study found that at 6 months, the Manuka group had a mean difference in clinical attachment level of -0.5 mm compared to controls, along with significant improvements in probing depth, bleeding on probing, and oral health-related quality of life.
Key findings
- Manuka honey group showed a mean difference in clinical attachment level of -0.5 mm at 6 months (P = .008).
- Significant improvements in probing depth and bleeding on probing were observed in the Manuka group (P = .013 and P = .005, respectively).
- The Manuka group had greater reductions in GCF FGF23 and serum CRP levels (P ≤ .001).
- Improvements in OHIP-14 scores were significantly greater in the Manuka group (P = .003).
Why it matters
The findings suggest that adjunctive Manuka honey oral rinse may enhance periodontal therapy outcomes in hemodialysis patients, a population at higher risk for periodontal disease. Improved clinical parameters and reduced inflammatory biomarkers could lead to better overall health and quality of life.