Nutritional Support With Or Without Exercise for Older Adults With GLIM-Compatible Malnutrition: A Meta-Analysis of Randomized Controlled Trials.
Clin TherAug 5, 2026 (epub)
Clinical ResearchGeriatrics
Xin Liu, Zhaoxin Jiang, Pan Liu et al.
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In 30 seconds
This meta-analysis evaluated the impact of adding exercise to nutritional support in older adults with GLIM-compatible malnutrition. Seventeen randomized controlled trials were analyzed, revealing that the combined intervention significantly improved lower limb strength (SMD 0.35; P < 0.0001) and usual walking speed (SMD 0.38; P = 0.008), but did not enhance upper limb strength or body composition.
Key findings
- Lower limb strength improved significantly with combined intervention (SMD 0.35; P < 0.0001).
- Usual walking speed showed a small improvement (SMD 0.38; P = 0.008).
- No significant difference in upper limb strength (SMD 0.15; P = 0.07).
- Muscle mass and lean body mass did not show significant changes.
Why it matters
Understanding the benefits of combining exercise with nutritional support can help clinicians optimize rehabilitation strategies for malnourished older adults, potentially enhancing their physical function and mobility.