Natural Agents for Preventing Skin Damage Induced by Visible Light: A Systematic Review of Preclinical and Clinical Evidence.
Azahara Rodríguez-Luna, Alicia Zamarrón, Cristina García-Muñoz et al.
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In 30 seconds
This systematic review evaluated preclinical and clinical evidence on the photoprotective effects of natural compounds against visible light (VL)-induced skin damage. The review found that natural compounds can mitigate oxidative stress and inflammation, with clinical studies indicating improvements in VL-induced erythema and pigmentation. However, significant variability in study designs limited quantitative analysis.
Key findings
- Natural compounds reduced VL-induced oxidative stress and inflammation in preclinical studies.
- Clinical studies showed improvements in VL-induced erythema and pigmentation with natural compound formulations.
- Heterogeneity in irradiation protocols and outcome measures precluded quantitative meta-analysis.
- The strongest clinical evidence focused on natural sources of polyphenols.
Why it matters
Understanding the protective effects of natural compounds against visible light damage is crucial for developing effective photoprotection strategies, especially as conventional sunscreens offer limited protection in this spectrum.
What to keep in mind
Considerable heterogeneity in study designs and outcome measures limited the ability to perform a quantitative meta-analysis.