Relationships between cannabis and cocaine use in a randomized trial of combined buprenorphine and naltrexone for DSM-IV cocaine dependence.
Crystal L Smith, Amaya Pelagio, Alex Schmidt et al.
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In 30 seconds
This randomized controlled trial analyzed the relationship between tetrahydrocannabinol (THC) positive urine drug screens and cocaine positive urine drug screens in 301 participants undergoing treatment for cocaine dependence. Results indicated that those with THC positive screens had 1.47 times higher odds of also testing positive for cocaine compared to THC negative participants, suggesting a significant association between cannabis and cocaine use during treatment.
Key findings
- Participants with THC positive UDS had 1.47 times higher odds of submitting cocaine positive UDS.
- Time showed a very small decrease in the odds of submitting cocaine positive UDS over the study period.
- Females had 77% higher odds of submitting cocaine positive UDS compared to males.
Why it matters
Understanding the interplay between cannabis and cocaine use is crucial for optimizing treatment strategies for cocaine dependence. This study highlights the potential need for addressing cannabis use in patients undergoing cocaine treatment to improve outcomes.