Peripheral parenteral nutrition improves short-term nutritional status and inflammatory reaction after colorectal resection surgery: A randomized clinical trial.
Maximos Frountzas, Evgenia Mela, Dimitrios Stefanoudakis et al.
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In 30 seconds
This randomized controlled trial evaluated the effects of early postoperative peripheral parenteral nutrition (PPN) on nutritional status and inflammatory response in 207 patients after colorectal resection. The study found that PPN significantly improved nitrogen balance and reduced inflammatory markers compared to conventional saline treatment, with a notable difference in procalcitonin levels on postoperative day 3 (ratio of medians, 1.69; P = .008).
Key findings
- Patients receiving PPN had a significantly more positive nitrogen balance (β = -5.6; P < .001) compared to the control group.
- Procalcitonin levels were significantly higher in the saline group on postoperative day 3 (ratio of medians, 1.69; P = .008).
- Overall postoperative complications were 35% in the PPN group versus 42.3% in the control group (P = .278).
- Major complications (Clavien-Dindo ≥3) occurred in 25% of the PPN group compared to 28.9% in the control group (P = .696).
Why it matters
The findings suggest that early postoperative PPN can enhance nutritional recovery and mitigate inflammatory responses in patients undergoing colorectal surgery, potentially leading to improved outcomes and faster recovery.