Effect of levothyroxine therapy on albuminuria and glomerular function in patients with type 2 diabetes and subclinical Hypothyroidism: a randomized controlled pilot trial.
Diabetes Res Clin PractAug 6, 2026 (epub)
Arindam Naskar, Agnibho Mondal, Alex George et al.
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In 30 seconds
This randomized controlled pilot trial evaluated the impact of levothyroxine therapy on renal outcomes in 60 adults with type 2 diabetes and subclinical hypothyroidism over 6 months. The study found a significant decrease in urinary albumin-to-creatinine ratio (UACR) of -44.93 mg/g in the per-protocol analysis, while estimated glomerular filtration rate (eGFR) changes were not statistically significant.
Key findings
- UACR decreased by -13.09 mg/g with levothyroxine, while controls saw an increase of 31.84 mg/g.
- The per-protocol analysis showed a significant difference in UACR of -44.93 mg/g (p = 0.008).
- No adverse events were reported during the trial.
Why it matters
The findings suggest that levothyroxine may have a potential renoprotective effect in patients with type 2 diabetes and subclinical hypothyroidism, which could influence future management strategies for this population.