Outcomes of Intra-Arterial Tenecteplase after Endovascular Reperfusion for Acute Ischemic Stroke Due to Cardioembolism and Non-Cardioembolism: A Secondary Analysis of the POST-TNK Trial.
Miao Chai, Qin Zhang, Xuexiao Zhao et al.
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In 30 seconds
This secondary analysis of the POST-TNK randomized trial evaluated the safety and efficacy of intra-arterial tenecteplase (TNK) in 540 patients with acute ischemic stroke (AIS) due to cardioembolism (CE) and non-CE. In patients with CE, TNK significantly increased the odds of freedom from disability at 90 days (adjusted odds ratio, 1.80; p = 0.04), with no increase in mortality or intracranial hemorrhage.
Key findings
- Intra-arterial TNK increased the odds of freedom from disability at 90 days in CE patients (adjusted odds ratio, 1.80; p = 0.04).
- No significant differences in 90-day mortality or symptomatic intracranial hemorrhage were observed between TNK and control groups.
- Intra-arterial TNK did not improve functional outcomes in patients with AIS due to non-CE.
Why it matters
The findings suggest that adjunctive intra-arterial TNK may enhance recovery in patients with acute ischemic stroke due to cardioembolism who achieve near-complete reperfusion, without increasing safety risks. This could influence treatment strategies in this patient population.