Dissecting a Diagnostic Enigma, Multiple Bilateral Facial Nodules in a Middle Aged Woman.

Am J DermatopatholAug 7, 2026 (epub)
Case ReportDermatologyOncology (Medical)

Nasser Almadan, Reem Althubaiti, Ahmed Almotairi et al.

✦ AI-curated · Sources linked

Case in brief

A 40-year-old woman presented with multiple bilateral facial nodules in a zosteriform pattern, which had increased over 15 years. She experienced slight pain when consuming spicy food and had a family history of similar lesions in her sister. Biopsy confirmed pilar leiomyoma, and immunohistochemistry indicated loss of fumarate hydratase, leading to the diagnosis of hereditary leiomyomatosis and renal cell carcinoma. Abdominal ultrasound revealed ovarian and uterine masses.

Diagnostic / clinical pearl

Clinicians should maintain a high index of suspicion for hereditary leiomyomatosis and renal cell carcinoma in patients with bilateral facial nodules arranged in a zosteriform pattern, as this may indicate an underlying syndrome.

Source

PubMed · PMID 42566391

Published in Am J Dermatopathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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