Diagnostic accuracy of nuclear STAT6 immunohistochemistry for solitary fibrous tumour: a systematic review and meta-analysis.
Ann Diagn PatholAug 6, 2026 (epub)
Clinical ResearchPathology (Anatomic & Clinical)
Vishal Tayade, Gyanendra Singh
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In 30 seconds
This systematic review and meta-analysis evaluated the diagnostic accuracy of nuclear STAT6 immunohistochemistry for solitary fibrous tumours (SFT) across 23 studies involving 1216 SFT and 4715 comparators. The analysis found a summary sensitivity of 98.7% and specificity of 99.1%, indicating that nuclear STAT6 is a reliable diagnostic marker for SFT.
Key findings
- Summary sensitivity of nuclear STAT6 immunohistochemistry was 98.7% (95% CI 96.7-99.5).
- Summary specificity was 99.1% (95% CI 97.8-99.6).
- The monoclonal YE361 subgroup achieved a specificity of 99.9% (99.3-100).
- False positives were primarily found in dedifferentiated liposarcoma and prostatic stromal tumours.
Why it matters
Accurate diagnosis of solitary fibrous tumours is crucial for appropriate management. The high sensitivity and specificity of nuclear STAT6 immunohistochemistry can aid pathologists in distinguishing SFT from other tumours, potentially improving patient outcomes.