First systematic mapping of non-target [68Ga]Ga-DOTANOC uptake across anatomical sites and etiologies.
Br J RadiolSep 30, 2026
Dhuha Al-Adhami, Ahmed Saad Abdlkadir, Nuha Saad Abdlkadir et al.
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In 30 seconds
This systematic review analyzed 76 studies involving 542 patients to map non-target [68Ga]Ga-DOTANOC uptake across various anatomical sites and etiologies. The findings revealed 799 non-target lesions, with 59.6% attributed to nononcologic causes. The abdomen was the most common site for these findings, highlighting the interpretive challenges in [68Ga]Ga-DOTANOC PET/CT imaging.
Key findings
- Nononcologic causes accounted for 59.6% of non-target [68Ga]Ga-DOTANOC-avid findings.
- The abdomen was the most common anatomical site, representing 38% of cases.
- Malignant oncologic and benign tumorous etiologies comprised 30.2% and 10.3%, respectively.
- A total of 799 non-target findings were reported across the studies.
Why it matters
Understanding the spectrum of non-target [68Ga]Ga-DOTANOC uptake is crucial for improving diagnostic accuracy in PET imaging. Clinicians can better interpret these findings, which may influence patient management and treatment decisions.