Impact of glucagon-like peptide-1 receptor agonists on outcomes following anterior cervical discectomy and fusion: a systematic review and meta-analysis.
Eur Spine JAug 8, 2026 (epub)
Dave Osinachukwu Duru, David Kwan Ryung Lee, Chloe Edmonds et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis evaluated the impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on outcomes following anterior cervical discectomy and fusion (ACDF) in a cohort of 311,402 patients. The analysis revealed that GLP-1RA users had significantly lower odds of pseudarthrosis at 6 months (OR=0.60), 12 months (OR=0.62), and 24 months (OR=0.67).
Key findings
- GLP-1RA users had lower odds of pseudarthrosis at 6 months (OR=0.60).
- At 12 months, the odds of pseudarthrosis were also lower for GLP-1RA users (OR=0.62).
- At 24 months, GLP-1RA users continued to show lower odds of pseudarthrosis (OR=0.67).
- Other postoperative complications showed heterogeneous and inconsistent findings.
Why it matters
Understanding the effects of GLP-1RAs on surgical outcomes is crucial for optimizing patient management in those undergoing ACDF, particularly regarding the risk of pseudarthrosis.