Dynamic nature of maternal multiple RBC alloantibodies after vaccination: Case report and immunological mechanisms review.
Hana Safić Stanić, Zrinka Kruhonja Galić, Iva Lucija Burnać et al.
✦ AI-curated · Sources linked
Case in brief
A 35-year-old pregnant woman presented with multiple red blood cell alloantibodies, including anti-D, anti-C, anti-Fya, and anti-M, detected early in her pregnancy. Following routine vaccinations, a significant rise in anti-D and anti-C titers occurred, leading to fetal anemia as indicated by elevated MCA-PSV. The patient underwent two intrauterine transfusions and delivered a healthy neonate who required supportive care.
What made this case unusual
The rapid escalation of maternal alloantibody titers following routine vaccinations is noteworthy, suggesting potential immune modulation effects.
Diagnostic / clinical pearl
Clinicians should be aware of the potential for dynamic changes in maternal alloantibody levels, particularly following vaccinations, and the importance of serial monitoring in managing pregnancies with multiple alloantibodies.
Why it matters
Understanding the immunological responses to vaccination in pregnant women with alloantibodies can inform clinical practices and improve outcomes in cases of hemolytic disease of the fetus and newborn.