Meta-Analysis: Prevalence of Non-Helicobacter pylori, Non-NSAID Peptic Ulcer Disease.
Aliment Pharmacol TherAug 10, 2026 (epub)
Clinical ResearchGastroenterology
Jun Watanabe, Hiromi Sekiguchi, Takeshi Kanno et al.
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In 30 seconds
This meta-analysis examined the prevalence of non-H. pylori, non-NSAID peptic ulcer disease (PUD) in adults, analyzing 92 studies with 60,816 patients. The findings revealed that 13.0% of overall PUD cases were non-H. pylori, non-NSAID, with 11.3% in bleeding PUD and 22.0% in perforated PUD, indicating a significant presence of this subgroup.
Key findings
- The pooled proportion of non-H. pylori, non-NSAID PUD was 13.0% in overall PUD.
- In bleeding PUD, the proportion was 11.3%.
- For perforated PUD, the proportion reached 22.0%.
- A more recent study year correlated with a higher proportion of bleeding PUD (β = 0.076).
Why it matters
Understanding the prevalence of non-H. pylori, non-NSAID PUD is crucial for clinicians to recognize and manage this distinct subgroup effectively, as it may influence treatment strategies and patient outcomes.