Blood Pressure Targets During General Anaesthesia in High-Risk Patients-A Randomised Clinical Feasibility Trial.
Acta Anaesthesiol ScandSep 1, 2026
Maria B Pælestik, Benjamin H Risager, Signe Ø Mortensen et al.
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In 30 seconds
This multicenter randomized clinical trial evaluated the feasibility of different blood pressure targets during general anaesthesia in 483 high-risk patients (ASA 3-5). The study found that while blood pressure separation was achieved, the MAP-80 mmHg group experienced more complications, including acute kidney injury and cardiac arrhythmias, compared to the MAP-60 mmHg group.
Key findings
- 483 patients were randomized, achieving blood pressure separation during treatment.
- Acute kidney injury was more common in the MAP-80 mmHg group (OR 4.74).
- Cardiac arrhythmias occurred more frequently in the MAP-80 mmHg group (OR 8.13).
- The MAP-80 mmHg group had a median difference of -1.88 days alive and out of hospital within 30 days.
Why it matters
Understanding optimal blood pressure targets during general anaesthesia is crucial for minimizing postoperative complications in high-risk patients. This study highlights the potential risks associated with higher blood pressure targets.