Physical, mental and biochemical effects of probiotics in multiple sclerosis: A systematic review and meta-analysis.
Tamar Blanca-Serrano, Marina Agredano-Sánchez, Rosa María López Gigosos et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of probiotic supplementation on physical, mental, and biochemical outcomes in adults with multiple sclerosis (MS). Analyzing six randomized placebo-controlled trials with 282 participants, the study found significant benefits in motor outcomes, particularly fatigue and pain, but no improvements in disability status or mental health outcomes. Biochemical analyses indicated moderate benefits in reducing systemic inflammatory markers.
Key findings
- Probiotic supplementation significantly improved fatigue and pain in MS patients.
- No significant changes were observed in disability status measured by the Expanded Disability Status Scale.
- Biochemical analyses showed reductions in systemic inflammatory markers, including high-sensitivity C-reactive protein.
- Mental health outcomes, including depression, did not demonstrate statistically significant changes.
Why it matters
Understanding the potential benefits of probiotics in managing symptoms of multiple sclerosis can inform treatment strategies. Clinicians may consider probiotics as a complementary approach for symptom relief, particularly for fatigue and pain, while recognizing the limited evidence for mental health improvements.