Breast implant-associated squamous cell carcinoma (BIA-SCC): Clinicopathologic analysis of two cases with radiologic-pathologic correlation and a review of the literature.
Anna-Lee Clarke-Brodber, Pei-Ling Chen, Abid Ulhaque et al.
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Case in brief
This report details two cases of breast implant-associated squamous cell carcinoma (BIA-SCC) in women in their 50s, presenting with breast pain and swelling one to two decades post-implantation. Imaging revealed seromas and potential masses. Cytologic analysis of seroma fluid in one case identified squamous cells. Clinical outcomes varied, with one patient experiencing aggressive disease and the other remaining free of recurrence after capsulectomy.
Diagnostic / clinical pearl
The presence of squamous cells in aspirate cytology from a late-onset peri-implant seroma may indicate BIA-SCC, warranting further investigation.
Why it matters
Increased awareness of BIA-SCC can lead to earlier diagnosis and improved management strategies for patients with suspicious peri-implant lesions.