Clinical and pathological outcomes of brachytherapy application for the treatment of high-grade vaginal squamous intraepithelial lesions: a systematic review.
Int J Gynecol CancerJul 29, 2026 (epub)
Clinical ResearchObstetrics & Gynecology
Carlos Felipe Durán Méndez, Juan Carlos Mendieta Redondo, Juan Sebastián Obando Rodríguez et al.
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In 30 seconds
This systematic review evaluated the efficacy and safety of intracavitary brachytherapy for treating high-grade vaginal squamous intraepithelial lesions (HSIL/VaIN2-3) in 225 women. The study found that local control rates ranged from 85% to 95%, with low rates of disease persistence (2.7%) and recurrence (1.7%).
Key findings
- Local control rates for brachytherapy ranged from 85% to 95%.
- Only 2.7% of patients experienced persistent disease.
- Recurrence rates were 1.7% among patients with specific data.
- Late grade ≥3 vaginal stenosis or ulceration increased at higher doses.
Why it matters
Understanding the effectiveness and safety profile of brachytherapy for HSIL/VaIN2-3 is crucial for clinicians managing patients with these lesions, particularly in selecting appropriate treatment modalities and anticipating potential complications.