Individualized Connectivity-Guided Versus Conventional Targeting of Accelerated Theta-Burst Stimulation in Depression: A Randomized, Double-Blind, Parallel-Design Trial.
Mingzhu Li, Zijia Wu, Xuefeng Lu et al.
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In 30 seconds
This randomized, double-blind trial evaluated the efficacy of individualized connectivity-guided intermittent theta-burst stimulation (iTBS) versus conventional 5-cm targeting in adults aged 18-65 with major depressive disorder or bipolar II depression. The study found that SC-guided iTBS resulted in a significant reduction in Hamilton Depression Rating Scale (HAM-D) scores at week 2, with a least squares mean difference of 8.79 percentage points compared to the 5-cm rule.
Key findings
- SC-guided iTBS showed an 8.79 percentage point greater reduction in HAM-D scores at week 2 compared to the 5-cm rule.
- At week 6, SC-guided iTBS had a 12.87 percentage point improvement over the 5-cm group.
- FC-guided iTBS also outperformed the 5-cm group at week 6 with a 9.41 percentage point difference.
Why it matters
The findings suggest that using connectivity-guided targeting for iTBS may enhance treatment outcomes in patients with depression, potentially leading to more effective personalized treatment strategies in clinical practice.