Individualized vs Standard Blood Pressure Control During Thrombectomy for Ischemic Stroke: The DETERMINE Randomized Clinical Trial.
NeurologyAug 12, 2026 (epub)
Benjamin Maïer, Benjamin Gory, Russell Chabanne et al.
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In 30 seconds
The DETERMINE randomized clinical trial evaluated individualized blood pressure (BP) control during mechanical thrombectomy for ischemic stroke in 433 patients. The study found no significant difference in favorable functional outcomes at 90 days between the individualized BP group (44.2%) and the control group (48.8%), with an adjusted odds ratio of 0.82 (95% CI 0.54-1.24; p = 0.34).
Key findings
- Favorable functional outcome at 90 days was 44.2% in the individualized BP group vs 48.8% in the control group.
- Mortality at 90 days was 18.8% in the individualized BP group compared to 16.4% in the control group.
- No significant differences in symptomatic intracranial hemorrhages were observed between the two groups.
Why it matters
This study challenges the current one-size-fits-all approach to blood pressure management during thrombectomy, suggesting that individualized control may not improve functional outcomes for patients with acute ischemic stroke.