Mobile health apps improve Health-Related Quality of Life in Type 2 Diabetes Mellitus by enhancing medication adherence: A multicentre randomised controlled trial with mediation analysis.
Prim Care DiabetesAug 13, 2026 (epub)
Clinical ResearchEndocrinology
Mohd Syamir Mohamad Shukeri, Baharudin Ibrahim, Siew Chin Ong et al.
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In 30 seconds
This multicentre randomized controlled trial evaluated the impact of the gamified mHealth application CareAide® on Health-Related Quality of Life (HRQoL) in 663 patients with Type 2 Diabetes Mellitus. The study found that CareAide® significantly improved medication adherence, which fully mediated the improvement in HRQoL as measured by AQoL-6D, with a mean difference in MMAS-8 scores of +1.756 (p < 0.001).
Key findings
- CareAide® led to a significant increase in MMAS-8 scores with a mean difference of +1.756 (p < 0.001).
- Higher MMAS-8 scores predicted improved AQoL-6D utility (b = 0.024; p < 0.001).
- The bootstrapped indirect effect confirmed full mediation via AQoL-6D (0.042; 95% CI [0.024, 0.060]).
- EQ-5D-5L utility showed a significant direct between-group difference at 6 months (p = 0.012).
Why it matters
Improving medication adherence through digital interventions like CareAide® can enhance the quality of life for patients with Type 2 Diabetes Mellitus, potentially leading to better disease management and outcomes.