Vitamin D Deficiency During Pregnancy Is Associated With Greater LDL-C Increase, Elevated β-Hydroxybutyrate and Altered Neonatal Metabolic Markers-A Secondary, Pooled Analysis of the Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI).
Jürgen Harreiter, Teresa Gisinger, Lilian C Mendoza et al.
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In 30 seconds
This secondary analysis of a randomized controlled trial examined the impact of maternal vitamin D status on lipid and metabolic markers in 962 pregnant women with overweight or obesity. The study found that vitamin D deficiency before 20 weeks' gestation was associated with significantly greater increases in LDL cholesterol and β-hydroxybutyrate levels during pregnancy compared to sufficient levels, highlighting the importance of maternal vitamin D status on metabolic adaptations.
Key findings
- Women with vitamin D deficiency had significantly larger increases in LDL-C throughout pregnancy compared to those with sufficiency.
- At 24-28 weeks' gestation, β-hydroxybutyrate levels were elevated in vitamin D deficient women.
- Cord blood vitamin D levels were highest in offspring of mothers with sufficient vitamin D.
- Higher β-hydroxybutyrate levels were observed in cord blood of infants from vitamin D deficient mothers.
Why it matters
Understanding the relationship between maternal vitamin D status and metabolic changes during pregnancy is crucial, as it may influence both maternal health and fetal development. This knowledge can inform clinical practices regarding vitamin D monitoring and supplementation in pregnant women.