Skin cell suspension autograft as an evidence-based innovation in burn and wound treatment: A systematic review of global evidence across two decades.
Anju B Saraswat, Jeremy M Rawlins, Jeffrey E Carter et al.
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In 30 seconds
This systematic review evaluated the clinical use of skin cell suspension autograft (SCSA) for wound closure across 99 studies from 13 countries. SCSA was found to reduce donor skin use, with healing outcomes favoring SCSA in 61% of comparative studies. The review highlights SCSA's potential benefits in various wound types and contexts.
Key findings
- SCSA reduced donor skin use in 61% of comparative studies.
- Healing outcomes favored SCSA in 61% of cases, while 39% reported equivalent outcomes.
- Pain and esthetic outcomes more frequently favored SCSA compared to controls.
- Health-economic outcomes suggested potential reductions in length of stay and resource utilization.
Why it matters
Understanding the effectiveness of SCSA can inform clinicians about innovative wound management strategies that may enhance healing and reduce resource use, ultimately improving patient care in burn and wound treatment.
What to keep in mind
The review noted limitations such as heterogenous study designs, variable outcome reporting, and a predominance of non-randomized data.