Protocol for the CLOCKS study: A 4-arm randomized controlled trial testing the independent and combined effects of 2 chronotherapies-early time-restricted eating and daytime bright light therapy-in adults with type 2 diabetes.
Nutr ResJul 17, 2026 (epub)
Felicia L Steger, Sarah-Jeanne Salvy, T Brooks Vaughan et al.
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In 30 seconds
The CLOCKS study is a 4-arm randomized controlled trial investigating the effects of early time-restricted eating (eTRE) and daytime bright light therapy (BLT) on glycemic control in 344 adults with type 2 diabetes. The primary outcome is glycemic control, measured by HbA1c and 24-hour glucose, over a 16-week intervention period with follow-up at one year.
Key findings
- Participants will be randomized into four groups: control, eTRE, BLT, or eTRE + BLT.
- eTRE involves eating within an 8-hour window ending by 17:00.
- BLT participants will receive bright light for 90 min/day before 15:00.
- The study aims to assess multiple health outcomes, including glucose metabolism and psychological health.
Why it matters
This study addresses the potential of chronotherapies to enhance glycemic control and overall health in adults with type 2 diabetes, a population at high risk for cardiovascular complications. Understanding these interventions could inform future treatment strategies.