Immune checkpoint inhibitors in the management of oral mucosal melanoma.

J Stomatol Oral Maxillofac SurgAug 13, 2026 (epub)
Clinical ResearchOncology (Medical)

Niko Paavilainen, Sara Degerholm, Tuula Salo et al.

✦ AI-curated · Sources linked

Condensed from the publisher's abstract. An xxcode editorial summary of this publication has not been generated yet.

From the abstract

Oral mucosal melanoma (OMM) is a rare, aggressive malignancy biologically distinct from cutaneous melanoma. Given complex anatomy and limited chemotherapy efficacy, immune checkpoint inhibitors (ICIs) are increasingly used. This systematic review evaluated the clinical outcomes and safety of ICIs in primary OMM.

Reported results

Fourteen case reports and two cohorts (n = 124) met the inclusion criteria. The mean age in case reports was 65 years, with the maxilla as the predominant site. The majority of patients had advanced disease (IVa 57.1%). RECIST assessments indicated one complete response with pembrolizumab and topical imiquimod and partial responses in 9 of 14 patients (64.3%). Survival ranged from 3 to >96 months (mean ∼25).

Authors' conclusions

Findings derived from case reports and two cohort studies suggest clinically meaningful responses and survival benefits of ICIs in a subset of patients with advanced OMM.

Source

PubMed · PMID 42595090

Published in J Stomatol Oral Maxillofac Surg. The text above is extracted from the publisher's own abstract and has not been edited by xxcode. For clinical decisions, review the original publication.

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