Updating the evidence on brighton collaboration's GAIA maternal immunisation case definitions: a systematic review of performance and implementation challenges.
Robert Mboizi, Kirsten Maertens, Kirsty Le Doare et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review evaluated the performance of the Brighton Collaboration's GAIA maternal immunisation case definitions across various settings. Analyzing 10 studies with 42,587 cases, it was found that while definitions for maternal and neonatal death performed well, many others had high rates of unclassifiable cases, achieving only LOC-4. Approximately half of the GAIA case definitions remain unevaluated.
Key findings
- Three case definitions had not been evaluated: ectopic pregnancy, postpartum endometritis, and neurodevelopmental delay.
- Some definitions achieved only LOC-4, with variability in classification rates from 50% to 100% across studies.
- Around half of the GAIA case definitions have not been assessed in real-world settings.
Why it matters
Understanding the performance of maternal immunisation case definitions is crucial for ensuring accurate safety monitoring. This review highlights the need for improved evaluation and standardization to enhance maternal and neonatal health outcomes globally.