Developmental Dysplasia of the Hip in Saudi Arabia and the Gulf Countries: A Genetic Systematic Review Study .
Saudi Med JAug 6, 2026 (epub)
Naif Z Alrashdi, Ahmed M Almansour, Azfar Jamal
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In 30 seconds
This systematic review examined genetic determinants of developmental dysplasia of the hip (DDH) in Saudi Arabia and Gulf countries. Eleven studies were included, revealing correlations between DDH and genetic variants, particularly in HSPG2 and ATP2B4, alongside familial clustering and environmental influences. The findings suggest a multifactorial etiology for DDH in this population.
Key findings
- Correlations were found between DDH and genetic variants in HSPG2 and ATP2B4.
- The review included 11 studies out of 473 articles retrieved.
- A high degree of familial clustering and female dominance was noted.
- Environmental factors, such as swaddling practices, may interact with genetic susceptibility.
Why it matters
Understanding the genetic and environmental factors contributing to DDH can inform early detection and prevention strategies. This knowledge is crucial for clinicians working in regions with high prevalence rates, enabling better management of affected populations.