Immune Checkpoint Inhibitor-Associated Hemophagocytic Lymphohistiocytosis: Clinical Presentation and Outcomes in Three Patients.

J ImmunotherSep 15, 2026 (epub)
Case ReportHematologyOncology (Medical)

Mayte G Martinez-Garza, Effrosyni Apostolidou, Hugo R Lara-Martinez et al.

✦ AI-curated · Sources linked

Case in brief

Three patients receiving immune checkpoint inhibitors presented with diverse clinical symptoms indicative of systemic inflammation. Upon evaluation, they were diagnosed with immune checkpoint inhibitor-associated hemophagocytic lymphohistiocytosis, a severe hyperinflammatory syndrome. Treatment involved dexamethasone and an immunosuppressive agent, leading to variable clinical responses among the patients.

Diagnostic / clinical pearl

Clinicians should maintain a high index of suspicion for hemophagocytic lymphohistiocytosis in patients undergoing immune checkpoint inhibitor therapy who exhibit systemic inflammatory symptoms.

Source

PubMed · PMID 42598906

Published in J Immunother. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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