Circular RNAs in amyotrophic lateral sclerosis.
Neurobiol DisAug 14, 2026 (epub)
Clinical ResearchNeurology
Reza Ataei, Javad Amini, Nima Sanadgol et al.
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In 30 seconds
This systematic review investigates the role of circular RNAs (circRNAs) in amyotrophic lateral sclerosis (ALS) and related motor neuron diseases. The study identifies several circRNAs that regulate ALS-related genes and demonstrates significant alterations in their expression in ALS-affected CNS tissues, suggesting their involvement in disease mechanisms.
Key findings
- Several circular RNAs regulate ALS-related genes, including those involved in oxidative stress and apoptosis.
- ALS-related circRNAs can sponge 20 RNA-binding proteins, indicating their regulatory potential.
- RNA-seq data confirmed significant alterations in the expression of host genes of ALS-related circRNAs in ALS patients.
Why it matters
Understanding the role of circRNAs in ALS may provide insights into the molecular mechanisms underlying the disease, potentially guiding future research and therapeutic strategies.