Association between the interleukin 17F rs763780 polymorphism and immune thrombocytopenia risk: A systematic review and meta-analysis.
CytokineAug 15, 2026 (epub)
Clinical ResearchHematology
Li Fan, Qingyang Huai, Zheng Zhang et al.
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In 30 seconds
This meta-analysis examined the association between the interleukin 17F rs763780 polymorphism and immune thrombocytopenia (ITP) risk, analyzing data from eight case-control studies with 805 ITP cases and 841 controls. The findings indicated that the A allele is associated with increased ITP risk, particularly in homozygote and recessive models, with significant results in specific subgroups.
Key findings
- The A allele of the rs763780 polymorphism was associated with increased ITP risk in homozygote and recessive models.
- Significant associations were found in the Chinese/Japanese and Egyptian subgroups.
- Children showed significant associations in some genetic models, while adults demonstrated significance across all models.
Why it matters
Understanding genetic risk factors for immune thrombocytopenia can help clinicians identify at-risk populations and tailor monitoring and management strategies. This meta-analysis provides insights into the role of the IL-17F polymorphism in ITP risk.